![]() The pathophysiology-based approach in assessing imaging findings in the degenerative spine can: (1) accurately characterise the process in the involved segment (2) identify the sequence of degenerative changes and predict further abnormalities (3) identify hidden or subtle abnormalities based on indirect signs (4) assist clinicians in finding the source of pain or neurological symptoms (5) identify the best treatment options for patients. Therefore, understanding the pathophysiology of these biomechanical changes in the spine is essential for radiologists to characterise radiological abnormalities. The pathogenesis of these changes in the spine is a biomechanically related continuum of alterations that evolve over time. All elements of the spine, including the intervertebral discs, joints, ligaments and bony structures, may undergo morphological changes that can be classified as degenerative.Īccurate and comprehensive interpretation of imaging findings relating to the degenerative spine can be challenging and sometimes even confusing because the word “degeneration” means different things to radiologists, neurologists, neurosurgeons and pathologists. ![]() ![]() The aetiology of the degenerative changes may be mechanical micro-insults or damage secondary to macro-insults, such as spinal fractures, spinal surgery not related to degenerative disc disease or significant metabolic processes, such as ochondrosis or mucoplysaccharidoses. Approximately 70% of applied axial compression is transmitted by the vertebral body and the intervertebral discs, with the remaining 30% of the load being distributed through the facet jointsĭegenerative change is considered a response to insults, such as mechanical or metabolic injury, rather than a disease. The FSU represents the smallest motion segment of the spine and exhibits biomechanical characteristics similar to those of the entire spine. The venture originated as a spinout from the Johns Hopkins Center for Bioengineering Innovation and Design.Functional spinal unit (FSU). Spine Align, LLC is a privately-held, Baltimore-based company developing a portfolio of intraoperative products that both assess and assist with corrective surgeries for spinal alignment. Nicholas Theodore, Co-Founder of Spine Align and Director of the Neurological Spine Program at the Johns Hopkins Hospital. My colleagues and I cannot wait to use this breakthrough technology in the operating room next year,” said Dr. “The Spine Align platform leverages the infrastructure of image-guided and robotic technologies to deliver the next generation of surgery. LiveAlignTM is just the first of many products in our portfolio that will seamlessly augment the art of surgery with digital feedback,” said Dr. “This funding round represents a tremendous milestone of being closer to positively impacting the lives of patients with our technology. Rockies Venture Club was proud to lead this funding round and found that many investors across the country saw the same potential in the company,” added Dave Harris, Director of Operations at Rockies Venture Club. “The solution that Spine Align has developed will have a dramatic impact on spinal surgery.
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